Risk Environments of Neurologic & Psychiatric Illness

Substance Use Disorder Neurobiology & Public Health Implications

Kim DD, Procyshyn RM, Jones AA, Gicas KM, Jones PW, Lee LHN, McLellan-Carich R, Panenka WJ, Leonova O, Lang DJ, Thornton AE, Honer WG, Barr AM. (2024) Relationship between drug-induced movement disorders and psychosis in adults living in precarious housing or homelessness. Psychiatry Research 170:290-296. doi: 10.1016/j.jpsychires.2024.01.003


Jones AA*, Cho LL*, Gicas KM, Procyshyn RM, Vila-Rodriguez F, Stubbs JL, Leonova O, Buchanan T, Thornton AE, Lang DJ, MacEwan GW, Panenka WJ, Barr AM, Field TS, Honer WG. (2023) Multilayer depressive symptom networks in adults with bodily pain living in precarious housing. European Archives of Psychiatry and Clinical Neuroscience 274(3):643-653. doi: 10.1007/s00406-023-01664-0


Stubbs JL, Jones AA, Wolfman D, Chan RCY, Vila-Rodriguez F, Vertinsky AT, Heran MK, Su W, Lang DJ, Field TS, Gicas KM, Woodward ML, Thornton AE, Barr AM, Leonova O, MacEwan GW, Rauscher A, Honer WG, Panenka WJ. (2023) Differential age-associated brain atrophy and white matter changes among homeless and precariously housed individuals compared to the general population. BMJ Neurology Open 5(1): e000349. doi: 10.1136/bmjno-2022-000349


Cho LL, Jones AA, Gao C, Leonova O, Vila-Rodriguez F, Buchanan T, Lang DJ, MacEwan GW, Procyshyn RM, Panenka WJ, Barr AM, Thornton AE, Gicas KM, Honer WG, Barbic SP. (2023) Assessing depressive symptoms in a homeless and precariously housed sample. Psychiatry Research 326:115331. 

doi: 10.1016/j.psychres.2023.115331


Kim DD, Procyshyn RM, Gicas KM, Jones PW, Lee LHN, Jones AA, Stubbs JL, Panenka WJ, Cho LL, Leonova O, Thornton AE, Lang DJ, Honer WG, Barr AM. (2023) Association of movement disorders with psychosis, cognition, and substance use in adults living in precarious housing or homelessness. Progress in Neuro-Psychopharmacology & Biological Psychiatry 126:110795. doi: 10.1016/j.pnpbp.2023.110795

 

Bates AT, Tse-Agha L, Agha A, Nunez J, Boyda HN, Jones AA, Barr AM, Honer WG, Vila-Rodriguez F. (2023) Reduction in substance-related composite harm scores through street soccer. Cureus 15(5):e39650. doi: 10.7759/cureus.39650


Jones AA, Cho LL, Kim DD, Barbic SP, Leonova O, Byford A, Buchanan T, Vila-Rodriguez F, Procyshyn RM, Lang DJ, Vertinsky AT, MacEwan GW, Rauscher A, Panenka WJ, Thornton AE, Barr AM, Field TS, Honer WG. (2022) Pain, opioid use, depressive symptoms, and mortality in adults living in precarious housing or homelessness: A longitudinal prospective study. PAIN (epub ahead of print) doi:10.1097/j.pain.0000000000002619


Cho LL, Jones AA, Barbic SP, Leonova O, Vila-Rodriguez F, Buchanan T, Lang DJ, MacEwan GW, Procyshyn RM, Panenka WJ, Barr AM, Thornton AE, Gicas KM, Honer WG. (2021) Psychometric properties and correlates of the Beck Depression Inventory in a community-based and homeless or precariously housed sample. Journal of Affective Disorders Reports. (epub ahead of print) https://doi.org/10.1016/j.jadr.2021.100229


Lei M, Rintoul K, Stubbs JL, Kim DD, Jones AA, Hamzah Y, Procyshyn RM, Gicas KM, Cho LL, Panenka WJ, Thornton AE, Lang DJ, MacEwan GW, Honer WG. (2021) Characterization of bodily pain and use of both prescription and non-prescription opioids in tenants of precarious housing. Substance Use and Misuse (epub ahead of print)  doi: 10.1080/10826084.2021.1958865


Priest KC, Gorfinkel L, Klimas J, Jones AA, Fairbairn N, McCarty D. (2019) A policy discussion paper: A comparison of U.S. and Canadian opioid use disorder treatment policies. International Journal of Drug Policy 74:257-265.


Jones AA, Jang K, Panenka WJ, Barr AM, MacEwan GW, Thornton AE, Honer WG. (2018) Rapid change in fentanyl prevalence in a community-based, high-risk sample. JAMA Psychiatry 75(3):298-300.


Jones AA, Vila-Rodriguez F, Panenka WJ, Leonova O, Strehlau V, Lang DJ, Thornton AE, Wong H, Barr AM, Procyshyn RM, Smith GN, Buchanan T, Krajden M, Krausz M, Montaner JS, MacEwan GW, Nutt DJ and Honer WG. (2013) Personalized risk assessment of drug-related harm is associated with health outcomes. PLOS ONE 8(11):e79754.

deBacker J, Hawken ER, Normandeau CP, Jones AA, di Prospero C, Mechefske E, Gregory JG, Hayton SJ, Dumont EC. (2014) GluN2B blockade rescues bidirectional synaptic plasticity in the bed nucleus of the stria terminalis of cocaine self-administering rats. Neuropsychopharmacology doi:10.1038/npp.2014.182


Krawczyk M, deBacker J, Mason X, Jones AA, Dumont EC. (2014) Dopamine decreases NMDA currents in the oval bed nucleus of the stria terminalis of cocaine self-administering rats. Progress in Neuro-Psychopharmacology & Biological Psychiatry 51:83-88.


Krawczyk M, Mason X, deBacker J, Sharma R, Normandeau CP, Hawken ER, di Prospero C, Chiang C, Martinez A, Jones AA, Doudnikoff E, Caille S, Bezard­­­­­ E, Georges F, Dumont EC. (2013) D1 dopamine receptor-mediated LTP at GABA synapses encodes motivation to self-administer cocaine in rats. The Journal of Neuroscience 33(29):11960-71.

 

Krawczyk M, Sharma R, Mason X, DeBacker J, Jones AA, Dumont EC. (2011) A switch in the neuromodulatory effects of dopamine in the oval bed nucleus of the stria terminalis associated with cocaine self-administration in rats. The Journal Neuroscience 31(24): 8928-35.

Psychosis Risk Factors, Trajectories, and Neural Correlates

Jones AA, Gicas KM, Mostafavi S, Woodward ML, Leonova O, Vila-Rodriguez F, Procyshyn RM, Cheng A, Buchanan T, Lang DJ, MacEwan GW, Panenka WJ, Barr AM, Thornton AE, Honer WG. (2021) Dynamic networks of psychotic symptoms in adults living in precarious housing or homelessness. Psychological Medicine, 1-11. doi:10.1017/S0033291720004444

Jones AA, Gicas KM, Seyedin S, Willi TS, Leonova O, Vila-Rodriguez F, Procyshyn RM, Smith GN, Schmitt TA, Vertinsky AT, Buchanan T, Rauscher A, Lang DJ, MacEwan GW, Lima VD, Montaner JSG, Panenka WJ, Barr AM, Thornton AE, Honer WG. (2020) A longitudinal, community-based study of the effects of substance use on psychosis, and mortality in people living in precarious housing or homelessness. PLoS Medicine 17(7):e1008172.

Gicas KM, Cheng A, Panenka WG, Kim DD, Yau JC, Procyshyn RM, Stubbs JL, Jones AA, Bains S, Thornton AE, Lang DJ, Vertinsky AT, Rauscher A, Honer WG, Barr AM. (2020) Differential effects of cannabis exposure during early versus later adolescence on the expression of psychosis in homeless and precariously housed adults. Progress in Neuropsychopharmacology & Biological Psychiatry 106:110084


Alexander PD, Gicas KM, Cheng A, Lang DJ, Rocyshyn RM, Vertinsky AT, Panenka WJ, Thornton AE, Rauscher A, Wong JYX, Chan T, Jones AA, Vila-Rodriguez F, Honer WG, Barr AM. (2019) A comparison of regional brain volumes and white matter connectivity in subjects with stimulant induced psychosis versus schizophrenia. Psychopharmacology 236(12):3385-3399.


Alexander PD, Gicas KM, Willi TS, Kim CN, Boyeva V, Procyshyn RM, Smith GN, Thornton AE, Panenka WJ, Jones AA, Vila-Rodriguez F, Lang DJ, MacEwan GW, Honer WG, Barr AM. (2017) A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence. Psychopharmacology 234(9-10):1535-47.


Morin F, Dhir A, Mitchell E, Jones AA. (2016) Social support: A useful tool in the management of psychotic disorders. UBC Medical Journal 8(2):10-12.

 

Willi TS, Honer WG, Thornton AE, Gicas K, Procyshyn RM, Vila-Rodriguez F, Panenka WG, Aleksic A, Leonova O, Jones AA, MacEwan W, Barr AM. (2016) Factors affecting severity of positive symptoms of psychosis in a polysubstance using population with psychostimulant dependence. Psychiatry Research 240:336-42.


Honer WG, Jones AA, Thornton AE, Barr AM, Procyshyn RM, Vila-Rodriguez, F. (2015) Response trajectories to clozapine in a secondary analysis of pivotal trials support using treatment response to subtype schizophrenia. Canadian Journal of Psychiatry 60(3 Suppl2):S19-25.

Multimorbidity & Mortality Among Precariously Housed Adults

Barbic SP*, Jones AA*, Woodward M, Piercy M, Mathias S, Vila-Rodriguez F, Leonova O, Smith GN, Buchanan T, Vertinsky AT, Gillingham S, Panenka WJ, Rauscher A, Barr AM, Procyshyn RM, MacEwan GW, Lang DJ, Thornton AE, Heran MK, Leon AM, Krausz M, Honer WG. (2018) Clinical and functional characteristics of young adults living in single room occupancy housing: Preliminary findings from a 10-year longitudinal study. Canadian Journal of Public Health 109(2):204-214.

* co-primary


Honer WG, Cervantes A, Jones AA, Vila-Rodriguez F, Montaner JS, Tran H, Nham J, Panenka W, Lang DJ, Thornton AE, Vertinsky T, Barr AM, Procyshyn RM, Smith GN, Buchanan T, Krajden M, Krausz M, MacEwan GW, Gicas KM, Leonova O, Langheimer V, Rauscher A, Schultz K. (2017) The hotel study - Clinical and health service effectiveness in a cohort of homeless or marginally housed persons. Canadian Journal of Psychiatry 62(7):482-92.

 

Jones AA, Willi TS, Honer WG. (2016) Mental illness and significant cognitive impairment among marginalized adults in Vancouver. UBC Medical Journal 8(1):12-13.


Jones AA, Vila-Rodriguez F, Leonova O, Langheimer V, Lang DJ, Barr AM, Procyshyn RM, Smith GN, Schultz K, Buchanan T, Krausz M, Montaner JSG, MacEwan GW, Rauscher A, Panenka WJ, Thornton AE, Honer WG. (2015) Mortality from treatable illnesses in marginally housed adults: A prospective cohort study. British Medical Journal Open 5(8):e008876.

Cognitive Impairment, Aging & Dementia

Jones AA, Ramos-Miguel A, Gicas KM, Petyuk VA, Leurgans SE, De Jager PL, Schneider JA, Bennett DA, Honer WG, Casaletto KB. (2024) A multilayer network analysis of Alzheimer’s disease pathogenesis: Roles for phosphor-tau, synaptic peptides, and physical activity. (accepted to Alzheimer’s & Dementia)


Blumberg MJ, Petersson AM, Jones PW, Jones AA, Panenka WJ, Leonova O, Vila-Rodriguez F, Lang DJ, Barr AM, MacEwan GW, Buchanan T, Honer WG and Gicas KM. (2024) Differential sensitivity of intraindividual variability dispersion and global cognition in the prediction of functional outcomes and mortality in precariously housed and homeless adults. (in press The Clinical Neuropsychologist)


Stubbs JL, Jones AA, Wolfman D, Chan RCY, Vila-Rodriguez F, Vertinsky AT, Heran MK, Su W, Lang DJ, Field TS, Gicas KM, Woodward ML, Thornton AE, Barr AM, Leonova O, MacEwan GW, Rauscher A, Honer WG, Panenka WJ. (2023) Differential age-associated brain atrophy and white matter changes among homeless and precariously housed individuals compared to the general population. BMJ Neurology Open 5(1): e000349. doi: 10.1136/bmjno-2022-000349

 

Gicas KM, Benitah K, Thornton AE, Petersson A, Jones P, Stubbs JS, Jones AA, Panenka WJ, Lang DJ, Leonova O, Vila-Rodriguez F, Barr AM, Buchanan T, Su W, Vertinsky AT, Rauscher A, MacEwan GW, Honer WG. (2023) Using serial position effects to investigate memory dysfunction in homeless and precariously housed persons. The Clinical Psychologist (epub ahead of print) doi.org/10.1080/13854046.2023.2178513


Baitz HA, Jones PW, Campbell DA, Jones AA, Gicas KM, Giesbrecht CJ, Thornton WL, Barone CC, Wang NY, Panenka WJ, Lang DJ, Vila-Rodriguez F, Leonova O, Barr AM, Procyshyn RM, Buchanan T, Rauscher A, MacEwan GW, Honer WG, Thornton AE. (2021) Component processes of decision making in a community sample of precariously housed persons: Associations with learning and memory, and health-risk behaviours. Frontiers of Psychology (epub ahead of print) https://doi.org/10.3389/fpsyg.2021.571423


Gicas KM, Jones AA, Thornton AE, Petersson A, Livingston E, Waclawik K, Panenka WJ, Barr AM, Lang DJ, Vila-Rodriguez F, Leonova O, Procyshyn RM, Buchanan T, MacEwan GW, Honer WG. (2020) Cognitive decline and mortality in a community-based sample of homeless and marginally housed adults: 9-year prospective study. British Journal of Psychiatry Open 5(e21):1-8.


Waclawik K, Jones AA, Barbic SP, Gicas KM, O’Connor TA, Smith GN, Leonova O, Mathias S, Barr AM, Procyshyn RM, Lang DJ, Woodward ML, MacEwan GW, Panenka WJ, Yamamoto A, Honer WG, Thornton AE. (2019) Cognitive impairment in marginally housed youth: Prevalence and risk factors. Frontiers in Public Health 7:270.


Gicas KM, Cheng A, Rawtaer I, Willi TS, Panenka WJ, Lang DJ, Smith GN, Vila-Rodriguez F, Leonova O, Giesbrecht CJ, Jones AA, Barr AM, Procyshyn RM, Buchanan T, MacEwan GW, Su W, Vertinsky AT, Rauscher A, O’Rourke N, Thornton W, Thornton AE, Honer WG. (2019) Diffusion tensor imaging of neurocognitive profiles in a community cohort living in marginal housing. Brain Imaging and Behaviour 9(3):e01233.

 

Gicas KM, Thornton AE, Waclawik K, Wang N, Jones AA, Panenka WJ, Lang DJ, Smith GN, Vila-Rodriguez F, Leonova O, Barr AM, Procyshyn RM, Buchanan T, Su W, Vertinsky AT, Rauscher A, MacEwan GW, Honer WG. (2019) Volumes of the hippocampal formation differentiate component processes of memory in a community sample of homeless and marginally housed persons. Archives of Clinical Neuropsychology 34(4):548-62.


Ramos-Miguel A, Jones AA, Sawada K, Barr AM, Bayer TA, Falkai P, Leurgans SE, Schneider JA, Bennett DA, Honer WG. (2018) Frontotemporal dysregulation of the SNARE protein interactome is associated with faster cognitive decline in old age. Neurobiology of Disease 114: 31-44.


Ramos-Miguel A, Sawada K, Jones AA, Thornton AE, Barr AM, Leurgans SE, Schneider JA, Bennett DA, Honer WG. (2017) Presynaptic proteins complexin-I and complexin-II differentially influence cognitive function in early and late stages of Alzheimer’s disease. Acta Neuropatholigica 133(3):395-407.


Gicas KM, Giesbrecht CJ, Panenka WJ, Lang DJ, Smith GN, Vila-Rodriguez F, Leonova O, Jones AA, Barr AM, Procyshyn RM, Buchanan T, MacEwan WG, Su W, Vertinsky T, Rauscher A, Honer WG, Thornton AE. (2017) Structural brain markers are differentially associated with neurocognitive profiles in socially marginalized people with multimorbid illness. Neuropsychology 31(1):28-43.

Stroke & Cerebral Small Vessel Disease

Jones AA, Peacock DJSJP, Guest W, Wilson LK, Zhou LW. (2024) Cortical venous thrombosis caused by venous compression by arachnoid cyst. The Neurohospitalist 14(4): 464-465. doi: 10.1177/19418744241262071.


Zhou LW, Panenka WJ, Al-Momen G, Gicas KM, Thornton AE, Jones AA, Woodward MS, Heran MKS, Vertinsky AT, Su W, Barr AM, MacEwan GW, Lang DJ, Rauscher A, Honer WG, Field TS. (2020) Cerebral small vessel disease, risk factors and cognition in tenants of precarious housing. Stroke 51(11):3271-78.

 

Zhou LW, Panenka WJ, Jones AA, Gicas KM, Thornton AE, Heran MKS, Volders D, Lang DJ, Vertinsky AT, Rauscher A, Su W, Barr AM, MacEwan GW, Honer WG, Field TS. (2019) Prevalence and risk factors of brain infarcts and associations with cognitive performance in tenants of marginal housing. Journal of American Heart Association 8(13):e011412.

Neuroinflammatory & Neuroinfectious Disorders

Jones AA, Chen T. (2021) Delayed opsoclonus-myoclonus syndrome following ovarian teratoma resection. Journal of Neuro-Ophthalmology (epub ahead of print) doi: 10.1097/WNO.0000000000001384.

Lo C, Jones AA, Chen T. (2021) Extensive herpes simplex virus 2 myeloradiculitis in an immunocompetent host. Canadian Journal of Neurological Sciences (epub ahead of print) doi: 10.1017/cjn.2021.187